49ers vs. Vikings Week 2 Picks, Predictions & Odds
The San Francisco 49ers head to Minnesota as 5.5-point favorites for a Week 2 clash between two 1-0 teams.
Both teams showcased their offensive capabilities in Week 1, with the Vikings defeating the Giants 28-6 and the 49ers putting to rest any Super Bowl hangover concerns with a dominant 32-19 victory over the New York Jets.
This game also marks a revenge opportunity for Vikings QB Sam Darnold, who served as a backup for the 49ers last season.
Game Overview
- Matchup: San Francisco 49ers vs. Minnesota Vikings
- Date and Time: September 15, 1 pm ET
- Location: U.S. Bank Stadium, Minneapolis, MN
| Team | Spread | Moneyline | Total |
| San Francisco 49ers | -5.5 (-115) | -260 | Over 45.5 (-110) |
| Minnesota Vikings | +5.5 (-105) | +215 | Under 45.5 (-110) |
As of September 11 at BetOnline
Week 2 Picks: 49ers vs. Vikings
49ers Moneyline (-260)
The moneyline is the safer option than laying the points with the 49ers.
The initial line for this game was set at -7 for the 49ers, but it dropped to +4.5 before their Monday night game due to concerns about Christian McCaffrey's injury and the Vikings' strong Week 1 performance. After the 49ers' impressive win, the line moved back to -5.5, and some markets have even reached Minnesota +6.
Despite Christian McCaffrey being sidelined, the 49ers dominated the Jets on Monday night. While McCaffrey's status for Week 2 remains uncertain, signs point to him sitting out. Jordan Mason's standout 147-yard performance against the Jets and the turf at Minnesota, which could aggravate McCaffrey's injury, suggest Mason will take the lead back role in Week 2.
Mason is a physical runner reminiscent of Marshawn Lynch's style. The Vikings did well against the Giants' run game, but their defense faced the more finesse-oriented Devin Singletary. Mason's tough running style could be a different challenge for Minnesota.
While the 49ers have a strong chance of winning, the situation is not ideal for them. They're traveling to the central time zone on short rest, facing a team in its home opener. Minnesota's fans will be energized after their Week 1 victory, and the Vikings have historically been a tough opponent for the 49ers at home.
Last season, the 49ers were 7-point favorites in Minnesota in Week 7 but lost 22-17, with Brock Purdy throwing one touchdown and two interceptions. In 2018, Kyle Shanahan's 49ers were 6-point underdogs in Week 1 and failed to cover the spread, losing 24-16 in a game that wasn't as close as the score indicated.
If you enjoy betting teasers and have another preferred pick, this game provides a viable teaser leg for the 49ers.
Betting Trends for 49ers vs. Vikings
- San Francisco Trends:
- 1-4 ATS in its last 5 games
- The total has gone OVER in 4 of San Francisco's last 5 games.
- 10-3 SU in its last 13 games
- 5-1 ATS in its last 6 road games
- Minnesota Trends:
- The total has gone OVER in 4 of Minnesota's last 5 games.
- 1-4 SU in its last 5 games
- The total has gone UNDER in 5 of Minnesota's last 6 games against San Francisco
While the 49ers are favored to win and appear well-positioned after their Week 1 performance, the Vikings could present a tough challenge at home, making the moneyline a safer play.
Keep an eye on injury updates and betting trends as game day approaches for any potential changes to the odds or betting strategy.
The San Francisco 49ers head to Minnesota as 5.5-point favorites for a Week 2 clash between two 1-0 teams.
Both teams showcased their offensive capabilities in Week 1, with the Vikings defeating the Giants 28-6 and the 49ers putting to rest any Super Bowl hangover concerns with a dominant 32-19 victory over the New York Jets.
This game also marks a revenge opportunity for Vikings QB Sam Darnold, who served as a backup for the 49ers last season.
Game Overview
- Matchup: San Francisco 49ers vs. Minnesota Vikings
- Date and Time: September 15, 1 pm ET
- Location: U.S. Bank Stadium, Minneapolis, MN
| Team | Spread | Moneyline | Total |
| San Francisco 49ers | -5.5 (-115) | -260 | Over 45.5 (-110) |
| Minnesota Vikings | +5.5 (-105) | +215 | Under 45.5 (-110) |
As of September 11 at BetOnline
Week 2 Picks: 49ers vs. Vikings
49ers Moneyline (-260)
The moneyline is the safer option than laying the points with the 49ers.
The initial line for this game was set at -7 for the 49ers, but it dropped to +4.5 before their Monday night game due to concerns about Christian McCaffrey's injury and the Vikings' strong Week 1 performance. After the 49ers' impressive win, the line moved back to -5.5, and some markets have even reached Minnesota +6.
Despite Christian McCaffrey being sidelined, the 49ers dominated the Jets on Monday night. While McCaffrey's status for Week 2 remains uncertain, signs point to him sitting out. Jordan Mason's standout 147-yard performance against the Jets and the turf at Minnesota, which could aggravate McCaffrey's injury, suggest Mason will take the lead back role in Week 2.
Mason is a physical runner reminiscent of Marshawn Lynch's style. The Vikings did well against the Giants' run game, but their defense faced the more finesse-oriented Devin Singletary. Mason's tough running style could be a different challenge for Minnesota.
While the 49ers have a strong chance of winning, the situation is not ideal for them. They're traveling to the central time zone on short rest, facing a team in its home opener. Minnesota's fans will be energized after their Week 1 victory, and the Vikings have historically been a tough opponent for the 49ers at home.
Last season, the 49ers were 7-point favorites in Minnesota in Week 7 but lost 22-17, with Brock Purdy throwing one touchdown and two interceptions. In 2018, Kyle Shanahan's 49ers were 6-point underdogs in Week 1 and failed to cover the spread, losing 24-16 in a game that wasn't as close as the score indicated.
If you enjoy betting teasers and have another preferred pick, this game provides a viable teaser leg for the 49ers.
Betting Trends for 49ers vs. Vikings
- San Francisco Trends:
- 1-4 ATS in its last 5 games
- The total has gone OVER in 4 of San Francisco's last 5 games.
- 10-3 SU in its last 13 games
- 5-1 ATS in its last 6 road games
- Minnesota Trends:
- The total has gone OVER in 4 of Minnesota's last 5 games.
- 1-4 SU in its last 5 games
- The total has gone UNDER in 5 of Minnesota's last 6 games against San Francisco
While the 49ers are favored to win and appear well-positioned after their Week 1 performance, the Vikings could present a tough challenge at home, making the moneyline a safer play.
Keep an eye on injury updates and betting trends as game day approaches for any potential changes to the odds or betting strategy.